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- 品牌：Bio-Rad
- 產(chǎn)地：國外
- 型號：0.2 mg
- 貨號：MCA2519
- 發(fā)布日期： 2022-08-26
- 更新日期： 2024-08-12
| 產(chǎn)地 | 國外 |
| 品牌 | Bio-Rad |
| 貨號 | MCA2519 |
| 保存條件 | 詳詢 |
| 用途 | 詳詢 |
| 應(yīng)用范圍 | 詳詢 |
| 抗原來源 | 詳詢 |
| CAS編號 | |
| 保質(zhì)期 | 詳詢 |
| 抗體名 | Mouse anti Human CD206 |
| 是否單克隆 | 是 |
| 克隆性 | 是 |
| 靶點 | 詳詢 |
| 適應(yīng)物種 | 詳詢 |
| 形態(tài) | 詳詢 |
| 宿主 | 詳詢 |
| 標記物 | 詳詢 |
| 包裝規(guī)格 | 0.2 mg |
| 純度 | 詳詢% |
| 亞型 | IgG2a |
| 標識物 | 詳詢 |
| 濃度 | 詳詢% |
| 免疫原 | Monocyte-derived dendritic cells. |
| 是否進口 | 是 |
產(chǎn)品名稱：Mouse anti Human CD206
產(chǎn)品描述：Mouse anti Human CD206 antibody, clone 7-450 recognizes human CD206, otherwise known as macrophage mannose receptor (MMR), a transmembrane protein and member of the multilectin family of pattern recognition receptors (PRRs), which mediates phagocytosis and endocytosis, and is modulated by a range of factors including cytokines, immunoglobulin receptors and pathogens.
CD206 has two extracellular lectin binding sites: the cysteine-rich domain binds to sulphated sugars of glycoproteins such as thyroid stimulating hormone, whilst the recognition of mannose and fucose occurs through carbohydrate recognition domains (CRDs). The widespread distribution and recognition of a wide range of antigens by macrophages, plays a key role in both innate and adaptive immunity, with CD206 able to bind to both gram-negative and gram-positive bacteria, mycobacterium, yeasts, fungi and parasites. The expression of CD206 is not restricted to macrophages, but is also present on immature dendritic cells (DCs), endothelial cells, kidney mesangial cells, retinal pigment epithelium and tracheal smooth muscle cells.
