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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：123125
- cas：1032900-25-6
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 123125 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0g; 2.0g; 5.0g; |
| CAS編號 | 1032900-25-6 |
| 純度 | >98%% |
| 是否進口 | 是 |
描述：Ceritinib也稱為LDK378，是ALK1的選擇性抑制劑，ALK1是一種在NSCLC中發(fā)現(xiàn)的靶點。在I期試驗中，LDK378在78例間變性NSCLC激酶陽性（ALK+）NSCLC患者中顯示出顯著的臨床反應(yīng)，這些患者在克唑替尼期間或之后有進展，或之前未接受過克唑替尼。LDK378阻斷ALK蛋白并阻止其向癌細(xì)胞發(fā)送生長信號，這可能會阻止cancer cells生長。Ceritinib于2014年4月獲得批準(zhǔn)。
產(chǎn)品名稱: Ceritinib free base
CAS#: 1032900-25-6 (free base)
分子式: C28H36ClN5O3S
分子量: 558.14
元素分析: C, 60.25; H, 6.50; Cl, 6.35; N, 12.55; O, 8.60; S, 5.75
Synonym: LDK-378; LDK378; LDK 378; Ceritinib, brand name: Zykadia.
IUPAC/Chemical Name: 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
InChi Key: VERWOWGGCGHDQE-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
SMILES Code: ClC1=CN=C(NC2=CC(C)=C(C3CCNCC3)C=C2OC(C)C)N=C1NC4=CC=CC=C4S(C(C)C)(=O)=O
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
