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RO9021
  • 品牌:MedKoo
  • 產(chǎn)地:美國(guó)
  • 貨號(hào):526669
  • cas:1446790-62-0
  • 發(fā)布日期: 2022-07-20
  • 更新日期: 2024-08-12
產(chǎn)品詳請(qǐng)
產(chǎn)地 美國(guó)
品牌 MedKoo
貨號(hào) 526669
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g;
CAS編號(hào) 1446790-62-0
純度 >98%%
是否進(jìn)口

Description: RO9021 is an oral, ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK). RO-9021 potently inhibited SYK kinase activity with an average IC50 of 5.6 nM. RO-9021 is a highly selective SYK inhibitor with low S-scores of 0.003 for S(99) and 0.015 for S(90), indicating that SYK is the only kinase with 99% competition with RO-9021 (1 uM) in a total of 392 tested kinases.

Name: RO9021
CAS#: 1446790-62-0
Chemical Formula: C18H25N7O
Exact Mass: 355.2121
Molecular Weight: 355.446
Elemental Analysis: C, 60.82; H, 7.09; N, 27.58; O, 4.50

Synonym: RO-9021; RO 9021; RO9021.

IUPAC/Chemical Name: 6-[(1R,2S)-2-Amino-cyclohexylamino]-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

InChi Key: XJZVCDVZCRLIKN-QWHCGFSZSA-N

InChi Code: InChI=1S/C18H25N7O/c1-10-7-8-15(21-11(10)2)23-14-9-16(24-25-17(14)18(20)26)22-13-6-4-3-5-12(13)19/h7-9,12-13H,3-6,19H2,1-2H3,(H2,20,26)(H2,21,22,23,24)/t12-,13+/m0/s1

SMILES Code: O=C(C1=NN=C(N[C@H]2[C@@H](N)CCCC2)C=C1NC3=NC(C)=C(C)C=C3)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001