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- 品牌：MedKoo
- 產地：美國
- 貨號：206849
- cas：1802929-43-6
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 206849 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號 | 1802929-43-6 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: PRN-1371 is an irreversible covalent pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively). It is selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 μM for all) but does inhibit colony stimulating factor 1 receptor (CSF1R) activity by greater than 90% at 1 μM. PRN-1371 inhibits proliferation in a panel of ten cancer cell lines containing various FGFR mutants (IC50s = 2-231 nM) and induces apoptosis in SNU-16 gastric and RT4 bladder cancer cells (EC50s = 15.9 and 11.8 nM, respectively). It reduces tumor growth in an SNU-16 mouse xenograft model and a patient-derived xenograft (PDX) mouse model of liver cancer when administered at a dose of 15 mg/kg twice per day.
Name: PRN-1371
CAS#: 1802929-43-6
Chemical Formula: C26H30Cl2N6O4
Exact Mass: 560.1706
Molecular Weight: 561.464
Elemental Analysis: C, 55.62; H, 5.39; Cl, 12.63; N, 14.97; O, 11.40
Synonym: PRN-1371; PRN1371; PRN 1371;
IUPAC/Chemical Name: 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
InChi Key: PUIXMSRTTHLNKI-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
SMILES Code: CNC1=NC=C2C(N(CCCN3CCN(C(C=C)=O)CC3)C(C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)=C2)=O)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
