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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：463562
- cas：2479378-45-3
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 463562 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; |
| CAS編號(hào) | 2479378-45-3 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4). It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM. PRGL493 reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.
Name: PRGL493
CAS#: 2479378-45-3
Chemical Formula: C25H21N7O2
Exact Mass: 451.1757
Molecular Weight: 451.49
Elemental Analysis: C, 66.51; H, 4.69; N, 21.72; O, 7.09
Synonym: PRGL493; PRGL 493; PRGL-493;
IUPAC/Chemical Name: N-(4-(3-(5-methylfuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-yl)acetamide
InChi Key: QNWGOBIYAPLFMK-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H21N7O2/c1-15-12-13-21(34-15)22-18(14-31(30-22)17-8-4-3-5-9-17)23-28-24(26-16(2)33)29-25-27-19-10-6-7-11-20(19)32(23)25/h3-14,23H,1-2H3,(H2,26,27,28,29,33)
SMILES Code: CC(NC1=NC2=NC3=C(N2C(N1)C4=CN(N=C4C5=CC=C(O5)C)C6=CC=CC=C6)C=CC=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
