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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：555277
- cas：1613373-33-3
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 555277 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 10.0mg; 25.0mg; |
| CAS編號 | 1613373-33-3 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: PCO371 is a potent and selective PTHR1 agonist for the treatment of hypoparathyroidism. Oral administration of PCO371 to osteopenic rats provokes a significant increase in bone turnover with limited increase in bone mass. In hypocalcemic rats, PCO371 restores serum calcium levels without increasing urinary calcium, and with stronger and longer-lasting effects than PTH injections.
Name: PCO371
CAS#: 1613373-33-3
Chemical Formula: C29H32F3N5O6S
Exact Mass: 635.2025
Molecular Weight: 635.6592
Elemental Analysis: C, 54.80; H, 5.07; F, 8.97; N, 11.02; O, 15.10; S, 5.04
Synonym: PCO371; PCO-371; PCO 371.
IUPAC/Chemical Name: 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro[4.5]dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione
InChi Key: LDZJFVOUPUFOHX-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44(41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)
SMILES Code: O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F)C=C4)N5)C5=O)=O)C(C)=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
