|
- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：464934
- cas：1132819-16-9
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 464934 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; |
| CAS編號(hào) | 1132819-16-9 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 μM, respectively). It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week. Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as adjuvants in stage III colon cancer.
Name: Oxaliplatin-d10
CAS#: 1132819-16-9
Chemical Formula: C8H4D10N2O4Pt
Exact Mass: 407.1229
Molecular Weight: 407.355
Elemental Analysis: C, 23.59; H, 5.93; N, 6.88; O, 15.71; Pt, 47.89
Synonym: Oxaliplatin-d10; Oxaliplatin d10; Lipoxal-d10; Lipoxal d10;
IUPAC/Chemical Name: N/A
InChi Key: ZROHGHOFXNOHSO-YYKMXZQESA-L
InChi Code: InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1/i1D2,2D2,3D2,4D2,5D,6D;;
SMILES Code: O=C1[O-][Pt+2]2([NH2][C@@]([2H])([C@@]3([NH2]2)[2H])C([2H])(C([2H])(C([2H])(C3([2H])[2H])[2H])[2H])[2H])[O-]C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
