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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：462849
- cas：2484895-50-1
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 462849 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號 | 2484895-50-1 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: NR-160 is a selective Histone Deacetylase 6 (HDAC6) Inhibitor with Bifurcated Capping Groups. NR-160 displayed only low cytotoxicity as a single agent against leukemia cell lines, it augmented the apoptosis induction of the proteasome inhibitor bortezomib in combination experiments significantly. Furthermore, a combinatorial high-throughput drug screen revealed significantly enhanced cytotoxicity when NR-160 was used in combination with epirubicin and daunorubicin. The synergistic effect in combination with bortezomib and anthracyclines highlights the potential of NR-160 in combination therapies.
Name: NR-160
CAS#: 2484895-50-1
Chemical Formula: C25H21F3N6O3
Exact Mass: 510.1627
Molecular Weight: 510.4772
Elemental Analysis: C, 58.82; H, 4.15; F, 11.17; N, 16.46; O, 9.40
Synonym: NR-160; NR160; NR 160;
IUPAC/Chemical Name: N-((1-benzyl-1H-tetrazol-5-yl)methyl)-N-(4-(hydroxycarbamoyl)benzyl)-2-(trifluoromethyl)benzamide
InChi Key: MEWDNULKAXEKII-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H21F3N6O3/c26-25(27,28)21-9-5-4-8-20(21)24(36)33(14-18-10-12-19(13-11-18)23(35)30-37)16-22-29-31-32-34(22)15-17-6-2-1-3-7-17/h1-13,37H,14-16H2,(H,30,35)
SMILES Code: O=C(NO)C1=CC=C(CN(CC2=NN=NN2CC3=CC=CC=C3)C(C4=CC=CC=C4C(F)(F)F)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
