|
- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：463923
- cas：1188487-83-3
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 463923 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號(hào) | 1188487-83-3 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells, which have constitutive STAT3 phosphorylation, with EC50 values of approximately 4.5 μM for both. It also decreases viability, migration, and invasion of, and induces apoptosis in, MCF-7, 4T1, and MDA-MB-231 breast cancer cells. Nifuroxazide reduces tumor growth and prevents pulmonary metastasis in a 4T1 murine mammary carcinoma model. It also reduces diarrhea, weight loss, and colon inflammation in a rat model of acetic acid-induced ulcerative colitis.
Name: Nifuroxazide-d4
CAS#: 1188487-83-3
Chemical Formula: C12H5D4N3O5
Exact Mass: 279.0793
Molecular Weight: 279.2444
Elemental Analysis: C, 51.61; H, 4.69; N, 15.05; O, 28.65
Synonym: Nifuroxazide-d4; Nifuroxazide d4;
IUPAC/Chemical Name: (E)-4-hydroxy-N'-((5-nitrofuran-2-yl)methylene)benzohydrazide-2,3,5,6-d4
InChi Key: YCWSUKQGVSGXJO-WNGOOFDKSA-N
InChi Code: InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+/i1D,2D,3D,4D
SMILES Code: O=C(N/N=C/C1=CC=C(O1)[N+]([O-])=O)C2=C(C([2H])=C(O)C([2H])=C2[2H])[2H]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
