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- 品牌：MedKoo
- 產地：美國
- 貨號：464419
- cas：1356929-49-1
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 464419 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號 | 1356929-49-1 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 μM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 μM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.1 It also reduces infarct volume in a rat model of focal cerebral ischemia when used at a concentration of 0.01 mg/kg.
Name: Moexipril-d5
CAS#: 1356929-49-1
Chemical Formula: C27H29D5N2O7
Exact Mass: 503.268
Molecular Weight: 503.6065
Elemental Analysis: C, 64.39; H, 7.80; N, 5.56; O, 22.24
Synonym: Moexipril-d5; Moexipril d5;
IUPAC/Chemical Name: (S)-2-(((S)-1-ethoxy-1-oxo-4-(phenyl-d5)butan-2-yl)-L-alanyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
InChi Key: UWWDHYUMIORJTA-SBCWFVTISA-N
InChi Code: InChI=1S/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1/i6D,7D,8D,9D,10D
SMILES Code: [2H]C1=C(C([2H])=C(C([2H])=C1CC[C@H](N[C@H](C(N2CC3=CC(OC)=C(C=C3C[C@H]2C(O)=O)OC)=O)C)C(OCC)=O)[2H])[2H]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
