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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：464488
- cas：1795142-30-1
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 464488 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號(hào) | 1795142-30-1 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH.3 Methazolamide is larvicidal, with a 50% larvicidal concentration (LC50) value of 724 ppm, but has no activity when administered in the diet to adult A. aegypti. Formulations containing methazolamide have been used in the treatment of glaucoma.
Name: Methazolamide-d6
CAS#: 1795142-30-1
Chemical Formula: C5H2D6N4O3S2
Exact Mass: 242.0414
Molecular Weight: 242.3006
Elemental Analysis: C, 24.79; H, 5.82; N, 23.12; O, 19.81; S, 26.46
Synonym: Methazolamide-d6; Methazolamide d6;
IUPAC/Chemical Name: (Z)-N-(3-(methyl-d3)-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide-d3
InChi Key: FLOSMHQXBMRNHR-OXIQCEOHSA-N
InChi Code: InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4-/i1D3,2D3
SMILES Code: O=C(C([2H])([2H])[2H])/N=C1SC(S(N)(=O)=O)=NN\1C([2H])([2H])[2H]
Appearance: Solid powder
Purity: >99% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
