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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：463880
- cas：1216527-48-8
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 463880 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號 | 1216527-48-8 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 μM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg. Formulations containing lornoxicam have been used in the management of postoperative pain.
Name: Lornoxicam-d4
CAS#: 1216527-48-8
Chemical Formula: C13H6D4ClN3O4S2
Exact Mass: 375.0052
Molecular Weight: 375.8344
Elemental Analysis: C, 41.55; H, 3.75; Cl, 9.43; N, 11.18; O, 17.03; S, 17.06
Synonym: Lornoxicam-d4; Lornoxicam d4; Chlortenoxicam-d4; Chlortenoxicam d4; Ro 13-9297-d4; Ro 13-9297 d4;
IUPAC/Chemical Name: 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl-d4)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
InChi Key: WLHQHAUOOXYABV-QFFDRWTDSA-N
InChi Code: InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)/i2D,3D,4D,5D
SMILES Code: OC(C1=C2C=C(Cl)S1)=C(N(S2(=O)=O)C)C(NC3=C(C([2H])=C(C([2H])=N3)[2H])[2H])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
