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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：535102
- cas：2410550-31-9
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 535102 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號 | 2410550-31-9 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: KVA-D-88 is an inhibitor of phosphodiesterase 4B (PDE4B). It is selective for PDE4B over a panel of 20 PDE isoforms and a panel of 39 CNS receptors at 10 μM but does inhibit the activity of PDE4C1, PDE3B, the serotonin receptor subtype 5-HT2C, and sigma-2 (σ2) receptors by greater than 50%. KVA-D-88 decreases LPS- or Pam3Cys-induced production of TNF-α in mouse bone marrow-derived macrophages. It reduces cocaine self-administration and the progressive ratio breakpoint in mice when administered at a dose of 5 mg/kg.
Name: KVA-D-88
CAS#: 2410550-31-9
Chemical Formula: C17H11Cl2F2N3O
Exact Mass: 381.0247
Molecular Weight: 382.1918
Elemental Analysis: C, 53.43; H, 2.90; Cl, 18.55; F, 9.94; N, 10.99; O, 4.19
Synonym: KVA-D-88; KVA-D 88; KVA-D88; KVAD-88; KVA D-88; KVAD88; KVA D 88;
IUPAC/Chemical Name: (1-(3,4-Dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)(3,3-difluoroazetidin-1-yl)methanone
InChi Key: JQEUSIGJVMRCOL-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H11Cl2F2N3O/c18-12-4-3-11(7-13(12)19)24-14(6-10-2-1-5-22-15(10)24)16(25)23-8-17(20,21)9-23/h1-7H,8-9H2
SMILES Code: O=C(C1=CC2=CC=CN=C2N1C3=CC=C(Cl)C(Cl)=C3)N4CC(F)(F)C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
