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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：574037
- cas：1402612-56-9
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 574037 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 5.0mg; 10.0mg; 25.0mg; 50.0mg; |
| CAS編號 | 1402612-56-9 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: KT172 is a non-selective inhibitor of diacylglycerol lipase α (DAGLα) and DAGLβ. It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol in HEK293T cell membranes expressing recombinant DAGLα or DAGLβ. KT172 also inhibits α/β-hydrolase 6 (ABHD6) and weakly inhibits monoacylglycerol lipase (MAGL). It restores nicotine-stimulated GABA release in isolated ventral tegmental area (VTA) dopamine neurons from rats chronically exposed to nicotine. KT172 decreases production of 2-arachidonoyl glycerol and subsequently reduces arachidonic acid, prostaglandin E2 (PGE2), and PGD2 in thioglycolate-stimulated peritoneal macrophages.
Name: KT172
CAS#: 1402612-56-9
Chemical Formula: C28H28N4O2
Exact Mass: 452.2212
Molecular Weight: 452.56
Elemental Analysis: C, 74.31; H, 6.24; N, 12.38; O, 7.07
Synonym: KT172, KT 172, KT-172
IUPAC/Chemical Name: [4-(2'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-methanone
InChi Key: MXVVJNJNDCJCFS-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H28N4O2/c1-34-27-13-6-5-12-25(27)22-14-16-23(17-15-22)26-20-32(30-29-26)28(33)31-18-8-7-11-24(31)19-21-9-3-2-4-10-21/h2-6,9-10,12-17,20,24H,7-8,11,18-19H2,1H3
SMILES Code: O=C(N1N=NC(C2=CC=C(C3=C(OC)C=CC=C3)C=C2)=C1)N4C(CC5=CC=CC=C5)CCCC4
Appearance: A crystalline solid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
