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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：462481
- cas：2252395-44-9
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 462481 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 5.0mg; 10.0mg; 50.0mg; |
| CAS編號 | 2252395-44-9 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1.
Name: J22352
CAS#: 2252395-44-9
Chemical Formula: C24H21N3O4
Exact Mass: 415.1532
Molecular Weight: 415.449
Elemental Analysis: C, 69.39; H, 5.10; N, 10.11; O, 15.40
Synonym: J22352; J-22352; J 22352
IUPAC/Chemical Name: 4-((2,4-dioxo-3-phenethyl-3,4-dihydroquinazolin-1(2H)-yl)methyl)-N-hydroxybenzamide
InChi Key: JBJIKUXUKSADFV-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H21N3O4/c28-22(25-31)19-12-10-18(11-13-19)16-27-21-9-5-4-8-20(21)23(29)26(24(27)30)15-14-17-6-2-1-3-7-17/h1-13,31H,14-16H2,(H,25,28)
SMILES Code: O=C(C1=CC=CC=C1N2CC3=CC=C(C(NO)=O)C=C3)N(CCC4=CC=CC=C4)C2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
