|
- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號(hào)：407172
- cas：868612-83-3
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號(hào) | 407172 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 5.0mg; 25.0mg; |
| CAS編號(hào) | 868612-83-3 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: IN-1130 is a highly selective small molecule ALK5 inhibitor with >100 fold selectivity over p38α and a panel of 26 other serine/threonine and tyrosine kinases. It is a suppressor of fibrogenic process of unilateral ureteral obstruction in rats underscoring the potential clinical benefits in the treatment of renal fibrosis. By inhibiting of TGF-β signaling, IN1130 ameliorated experimental autoimmune encephalomyelitis, lessened tunical fibrosis and corrected penile curvature in rats, inhibited cancer metastasis in MMTV/c-Neu breast cancer mice, and enhanced CTL response in cancer mice.
Name: IN-1130
CAS#: 868612-83-3
Chemical Formula: C25H20N6O
Exact Mass: 420.16986
Molecular Weight: 420.48
Elemental Analysis: C, 71.41; H, 4.79; N, 19.99; O, 3.80
Synonym: IN-1130; IN1130; IN 1130.
IUPAC/Chemical Name: 3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl) methyl)benzamide
InChi Key: RYKSGWSKILPDDY-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12,14H,13H2,1H3,(H2,26,32)(H,30,31)
SMILES Code: O=C(N)C1=CC=CC(CC2=NC(C3=CC=C4N=CC=NC4=C3)=C(C5=NC(C)=CC=C5)N2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
