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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：555348
- cas：2158197-70-5
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 555348 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; |
| CAS編號(hào) | 2158197-70-5 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis. HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action. Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation.
Name: HS-1371
CAS#: 2158197-70-5
Chemical Formula: C24H24N4O
Exact Mass: 384.195
Molecular Weight: 384.48
Elemental Analysis: C, 74.97; H, 6.29; N, 14.57; O, 4.16
Synonym: HS-1371; HS 1371; HS1371;
IUPAC/Chemical Name: 7-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline
InChi Key: VPVLPCIBKVWFDT-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
SMILES Code: CC1=CC=C(OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
