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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：464269
- cas：80154-34-3
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 464269 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; |
| CAS編號 | 80154-34-3 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: Helicid is a β-allopyranoside originally isolated from Helicia erratica that has diverse biological activities. It reverses decreases in serum corticosterone (CORT) levels and the expression of the serotonin (5-HT) receptor subtype 5-HT1A in rat hippocampus in a model of chronic unpredictable mild stress-induced depression when administered at a dose of 32 mg/kg per day. It also reverses stress-induced decreases in sucrose preference and immobility time in the forced swim test, indicating antidepressant-like activity, as well as decreases in locomotor activity, in the same model. Helicid increases the expression of the serotonin transporter (SERT) and reduces escape latency in the Morris water maze in a rat model of chronic unpredictable mild stress. It increases the mechanical allodynia threshold and increases non-rapid eye movement (NREM) sleep time in a manner dependent on the time-of-day of administration in a mouse model of partial sciatic nerve ligation.
Synonym: Helicid; 4-Formylphenyl β-D-Allopyranoside;
IUPAC/Chemical Name: 4-(((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde
InChi Key: OLZAGZCCJJBKNZ-SYLRKERUSA-N
InChi Code: InChI=1S/C13H16O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-5,9-13,15-18H,6H2/t9-,10-,11-,12-,13-/m1/s1
SMILES Code: OC[C@@H](O[C@H]1OC2=CC=C(C=O)C=C2)[C@@H](O)[C@@H](O)[C@H]1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
