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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：564903
- cas：339303-87-6
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 564903 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 10.0mg; 50.0mg; |
| CAS編號(hào) | 339303-87-6 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: ML 252 is a potent and selective inhibitor of KV7.2 voltage-gated potassium channels (IC50 = 70 nM), which displays >40-fold selectivity for KV7.2 over KV7.1 channels (IC50 = 2.9 μM for KV7.1). ML 252 is the (S)-enantiomer, and is more potent than the (R)-enantiomer or racemic mixture (IC50 values are 944 and 160 nM, respectively). ML 252 displays selectivity for KV7.2 over a panel of >68 GPCRs, ion channels and transporters. It inhibits melatonin MT1 receptor 60% at 10 μM. ML 252 is brain penetrant.
Name: ML 252
CAS#: 1392494-64-2
Chemical Formula: C20H24N2O
Exact Mass: 308.1889
Molecular Weight: 308.425
Elemental Analysis: C, 77.89; H, 7.84; N, 9.08; O, 5.19
Synonym: ML 252; ML-252; ML252;
IUPAC/Chemical Name: (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
InChi Key: FROGGFONBYACJB-KRWDZBQOSA-N
InChi Code: InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1
SMILES Code: O=C(NC1=C(C=CC=C1)N2CCCC2)[C@H](C3=CC=CC=C3)CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
