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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：464193
- cas：1185039-30-8
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 464193 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號(hào) | 1185039-30-8 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide. Gliclazide (5 and 10 μg/ml) reduces LDL oxidation by human aortic smooth muscle cells (HASMCs), decreasing TBARS content and 8-isoprostane levels. It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 μg/ml. Gliclazide (5 mg/kg) reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin (STZ).
Name: Gliclazide-d4
CAS#: 1185039-30-8
Chemical Formula: C15H17D4N3O3S
Exact Mass: 327.1555
Molecular Weight: 327.4354
Elemental Analysis: C, 55.02; H, 7.69; N, 12.83; O, 14.66; S, 9.79
Synonym: Gliclazide-d4; Gliclazide d4;
IUPAC/Chemical Name: N-((hexahydrocyclopenta[c]pyrrol-2(1H)-yl)carbamoyl)-4-methylbenzene-2,3,5,6-d4-sulfonamide
InChi Key: BOVGTQGAOIONJV-KDWZCNHSSA-N
InChi Code: InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)/i5D,6D,7D,8D
SMILES Code: CC1=C(C([2H])=C(C([2H])=C1[2H])S(NC(NN2CC3C(C2)CCC3)=O)(=O)=O)[2H]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
