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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：574018
- cas：145177-42-0
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 574018 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 5.0mg; 10.0mg; 50.0mg; 100.0mg; |
| CAS編號(hào) | 145177-42-0 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: GHRP-6 acetate is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It inhibits binding of the GHS-R agonist MK-0677 (Ibutamoren) to COS-7 cell membranes expressing human GHS-R type Ia and binding of ghrelin to COS-7 cells expressing human GHS-R. GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor and inositol phosphate production in COS-7 cells expressing the human receptor. It also acts as a negative allosteric modulator of ghrelin signaling. GHRP-6 induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland. It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.
Name: GHRP-6 acetate
CAS#: 145177-42-0
Chemical Formula: C52H68N12O12
Exact Mass: 1052.508
Molecular Weight: 1053.19
Elemental Analysis: C, 59.30; H, 6.51; N, 15.96; O, 18.23
Synonym: GHRP-6 acetate, Growth hormone releasing peptide 6 acetate, Hexapeptide-2, HWAWFK-NH2, SKF 110679, U 75799E
IUPAC/Chemical Name: L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, triacetate
InChi Key: XGWOPQAMQAZCJE-SLBOMMQWSA-N
InChi Code: InChI=1S/C46H56N12O6.3C2H4O2/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47;3*1-2(3)4/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64);3*1H3,(H,3,4)/t27-,34-,37-,38+,39+,40-;;;/m0.../s1
SMILES Code: O=C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N)=O)CCCCN)=O)[C@@H](NC([C@H](C)NC([C@H](NC([C@H](CC2=CN=CN2)N)=O)CC3=CNC4=C3C=CC=C4)=O)=O)CC5=CNC6=C5C=CC=C6.CC(O)=O.CC(O)=O.CC(O)=O
Appearance: A crystalline solid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
