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Floxuridine
  • 品牌：MedKoo
  • 產(chǎn)地：美國
  • 貨號：100360
  • cas：50-91-9
  • 發(fā)布日期： 2022-07-20
  • 更新日期： 2024-08-12
產(chǎn)品詳請
產(chǎn)地 美國
品牌 MedKoo
貨號 100360
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; 20.0g; 50.0g; 100.0g;
CAS編號 50-91-9
純度 >98%%
是否進(jìn)口 是
Description: Floxuridine is a fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Synonym: FdUrD; floxuridin; fluorodeoxyuridine; fluorouridine deoxyribose; fluoruridine deoxyribose. FUDF. 5FUDR; FDUR; FUdR. WR138720.

IUPAC/Chemical Name: 5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

InChi Key: ODKNJVUHOIMIIZ-RRKCRQDMSA-N

InChi Code: InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

SMILES Code: O=C1NC(C(F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in water (50 mg/ml), alcohol (1:12), isopropyl alcohol (1:43), methanol (1:7), aqueous buffers, acetone, DMSO (49 mg/ml) at 25 ?°C, and ethanol (10 mg/ml) at 25 ?°C. Insoluble in ether, benzene, and chloroform.

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001