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EVP-4593
  • 品牌：MedKoo
  • 產(chǎn)地：美國
  • 貨號：526642
  • cas：545380-34-5
  • 發(fā)布日期： 2022-07-20
  • 更新日期： 2024-08-12
產(chǎn)品詳請
產(chǎn)地 美國
品牌 MedKoo
貨號 526642
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g;
CAS編號 545380-34-5
純度 >98%%
是否進口 是
Description: EVP4593, also known as QNZ and CAY10470, is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. EVP4593 reduced the number of lysosomes/autophagosomes and SOC currents in HD GMSLNs and exerted neuroprotective effects during cell aging. EVP4593 may be a promising anti-HD drug.

Synonym: CAY10470; CAY-10470; CAY 10470; QNZ; EVP4593; EVP 4593; EVP-4593.

IUPAC/Chemical Name: N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine

InChi Key: IBAKVEUZKHOWNG-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)

SMILES Code: NC1=CC2=C(N=CN=C2NCCC3=CC=C(OC4=CC=CC=C4)C=C3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001