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Ethynylcytidine
  • 品牌：MedKoo
  • 產地：美國
  • 貨號：201330
  • cas：180300-43-0
  • 發(fā)布日期： 2022-07-20
  • 更新日期： 2024-08-12
產品詳請
產地 美國
品牌 MedKoo
貨號 201330
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 1.0mg; 5.0mg; 10.0mg;
CAS編號 180300-43-0
純度 >98%%
是否進口 是
Description: Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. 3'-C-ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation, and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Synonym: ECydTAS106TAS 1063CEthynylcytidineAIDS241582AIDS241582; SB596168 3Ethynylcytidine.

IUPAC/Chemical Name: 1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine

InChi Key: JFIWEPHGRUDAJN-DYUFWOLASA-N

InChi Code: InChI=1S/C11H13N3O5/c1-2-11(18)6(5-15)19-9(8(11)16)14-4-3-7(12)13-10(14)17/h1,3-4,6,8-9,15-16,18H,5H2,(H2,12,13,17)/t6-,8+,9-,11-/m1/s1

SMILES Code: O=C1N([C@H]2[C@@H]([C@]([C@@H](CO)O2)(C#C)O)O)C=CC(N)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001