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EP4 Receptor Antagonist 1
  • 品牌：MedKoo
  • 產(chǎn)地：美國
  • 貨號(hào)：463560
  • cas：2287259-07-6
  • 發(fā)布日期： 2022-07-20
  • 更新日期： 2024-08-12
產(chǎn)品詳請(qǐng)
產(chǎn)地 美國
品牌 MedKoo
貨號(hào) 463560
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg;
CAS編號(hào) 2287259-07-6
純度 >98%%
是否進(jìn)口 是
Description: EP4 receptor antagonist 1 is an antagonist of the prostaglandin E2 (PGE2) receptor EP4 that has an IC50 value of 6.1 nM in a calcium flux assay using CHO cells co-expressing the human receptor and Gα16. It is selective for EP4 over EP1, EP2, and EP3 receptors. EP4 receptor antagonist 1 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells expressing EP4. It reverses ERK phosphorylation induced by PGE2 in CHO cells expressing EP4 and decreases GM-CSF-induced expression of Il1b, Il4ra, Il6, Arg1, Cox2, and Il10 in RAW 264.7 cells when used at a concentration of 10 μM. EP4 receptor antagonist 1 reduces tumor volume and increases infiltration of CD8+ T cells into tumors in a murine colon carcinoma model.

Synonym: EP4 Receptor Antagonist 1; EP4-Receptor Antagonist 1;

IUPAC/Chemical Name: (S,E)-4-(1-(4-(prop-1-en-1-yl)-1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazole-5-carboxamido)ethyl)benzoic acid

InChi Key: ZTWUZRMXAVDXJV-XGACYXMMSA-N

InChi Code: InChI=1S/C23H21F3N4O3/c1-3-4-19-20(21(31)27-14(2)16-7-9-17(10-8-16)22(32)33)30(29-28-19)13-15-5-11-18(12-6-15)23(24,25)26/h3-12,14H,13H2,1-2H3,(H,27,31)(H,32,33)/b4-3+/t14-/m0/s1

SMILES Code: C[C@H](NC(C1=C(N=NN1CC2=CC=C(C=C2)C(F)(F)F)/C=C/C)=O)C3=CC=C(C(O)=O)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001