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| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 463372 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 10.0mg; 25.0mg; 50.0mg; 100.0mg; 250.0mg; 500.0mg; 1.0g; 2.0g; |
| CAS編號 | 57-97-6 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: 7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity. It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adducts in vivo, and it has been commonly used to induce tumor formation in various rodent models. DMBA increases proliferation and migration of, and induces epithelial-to-mesenchymal transition (EMT) in, MCF-10A breast cancer cells when used at a concentration of 5 μM. It also has immunosuppressant activity, inhibiting proliferation of isolated mouse splenic B- and T cells stimulated ex vivo with LPS or concanavalin A, respectively, when administered at doses of 50 and 100 mg/kg. Intragastric administration of DMBA (20 mg/animal) induces formation of mammary gland tumors in rats.6 DMBA (50 μg/animal), in combination with phorbol 12-myristate 13-acetate, initiates papilloma formation in a rat two-stage model of skin carcinogenesis.
Synonym: DMBA; 7,12-Dimethylbenz[a]anthracene; 7,12 Dimethylbenz[a]anthracene;
IUPAC/Chemical Name: 7,12-dimethyltetraphene
InChi Key: ARSRBNBHOADGJU-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
SMILES Code: CC1=C2C=CC=CC2=C(C3=C4C(C=CC=C4)=CC=C13)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
