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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：464668
- cas：514200-66-9
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 464668 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號 | 514200-66-9 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: COG133 is a peptide fragment of ApoE that corresponds to residues 133-149 of the ApoE LDL receptor-binding domain and an antagonist of α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 720 nM). It suppresses TNF-α and nitric oxide (NO) release in BV-2 microglia when used at concentrations ranging from 10 to 50 μM. In vivo, COG133 reduces LPS-induced increases in brain levels of TNF-α and IL-6 in mice. It decreases hippocampal neuronal degeneration and the latency to find the platform in the Morris water maze in a mouse model of closed head injury induced by surgical midline impact when administered at doses of 203 and 406 μg/kg. COG133 (1 mg/kg) also delays disease onset and reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).
Name: COG133 TFA salt
CAS#: 514200-66-9
Chemical Formula: C99H182F3N37O21
Exact Mass: 2282.4263
Molecular Weight: 2283.7782
Elemental Analysis: C, 52.07; H, 8.03; F, 2.50; N, 22.69; O, 14.71
Synonym: COG133 TFA salt; COG 133 TFA salt; COG-133 TFA salt; Ac-LRVRLASHLRKLRKRLL-NH2; ApoE (133-149); ApoE (133149); ApoE (133 149);
IUPAC/Chemical Name: (S)-2-((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S)-8-((1H-imidazol-5-yl)methyl)-2,20,26-tris(3-guanidinopropyl)-11-(hydroxymethyl)-5,17,29-triisobutyl-23-isopropyl-14-methyl-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazadotriacontanamido)-6-amino-N-((4S,7S,10S,13S,16S,19S)-13-(4-aminobutyl)-4-carbamoyl-10,16-bis(3-guanidinopropyl)-7-isobutyl-2,21-dimethyl-6,9,12,15,18-pentaoxo-5,8,11,14,17-pentaazadocosan-19-yl)hexanamide 2,2,2-trifluoroacetate
InChi Key: YRYTWYOGXATSSP-BGJGLIJFSA-N
InChi Code: InChI=1S/C97H181N37O19.C2HF3O2/c1-50(2)40-67(76(100)137)127-89(150)72(45-55(11)12)130-82(143)64(30-23-37-114-95(105)106)122-78(139)60(26-17-19-33-98)120-79(140)62(28-21-35-112-93(101)102)123-87(148)70(43-53(7)8)129-81(142)61(27-18-20-34-99)121-80(141)63(29-22-36-113-94(103)104)124-88(149)71(44-54(9)10)131-90(151)73(46-59-47-111-49-117-59)132-91(152)74(48-135)133-77(138)57(15)118-85(146)69(42-52(5)6)128-83(144)65(31-24-38-115-96(107)108)126-92(153)75(56(13)14)134-84(145)66(32-25-39-116-97(109)110)125-86(147)68(41-51(3)4)119-58(16)136;3-2(4,5)1(6)7/h47,49-57,60-75,135H,17-46,48,98-99H2,1-16H3,(H2,100,137)(H,111,117)(H,118,146)(H,119,136)(H,120,140)(H,121,141)(H,122,139)(H,123,148)(H,124,149)(H,125,147)(H,126,153)(H,127,150)(H,128,144)(H,129,142)(H,130,143)(H,131,151)(H,132,152)(H,133,138)(H,134,145)(H4,101,102,112)(H4,103,104,113)(H4,105,106,114)(H4,107,108,115)(H4,109,110,116);(H,6,7)/t57-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-;/m0./s1
SMILES Code: CC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)C)=O)CO)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)C(N)=O)C.FC(C(O)=O)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
