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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：530346
- cas：608512-97-6
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 530346 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 5.0mg; 10.0mg; 25.0mg; |
| CAS編號(hào) | 608512-97-6 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: C16, also known as GW-506033X or PKR Inhibitor. C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. GW-506033X protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. PKR inhibitor C16 binds efficiently with human microtubule affinity-regulating kinase 4.
Name: C16 (PKR Inhibitor)
CAS#: 608512-97-6
Chemical Formula: C13H8N4OS
Exact Mass: 268.0419
Molecular Weight: 268.294
Elemental Analysis: C, 58.20; H, 3.01; N, 20.88; O, 5.96; S, 11.95
Synonym: GW-506033X; GW 506033X; GW506033X; C16, PKR Inhibitor.
IUPAC/Chemical Name: 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
InChi Key: VFBGXTUGODTSPK-BAQGIRSFSA-N
InChi Code: InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
SMILES Code: O=C1/C(C2=C(SC=N3)C3=CC=C2N1)=C\C4=CN=CN4
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
