|
- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：522413
- cas：849773-63-3
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 522413 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 5.0mg; |
| CAS編號 | 849773-63-3 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: ARP-101 is a selective MMP-2 inhibitor that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively). ARP101 induces autophagy-associated cell death in cancer cells. ARP101 treatment was highly effective in inducing the formation of autophagosome and conversion of LC3I into LC3II. Moreover, ARP101-induced autophagy was completely blocked in mouse embryo fibroblasts that lacked autophagy related gene 5 (ATG5(-/-) MEF). ARP101 inhibited α-MSH-stimulated melanin synthesis and suppressed the expression of tyrosinase and TRP1 in immortalized mouse melanocytes. ARP101 also induced autophagy in melanocytes.
Synonym: ARP-101; ARP 101; ARP101.
IUPAC/Chemical Name: (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
InChi Key: DGZZVIWCMGVHGV-LJQANCHMSA-N
InChi Code: InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
SMILES Code: CC(C)[C@@H](N(OC(C)C)S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)C(NO)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
