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Apiin
  • 品牌：MedKoo
  • 產(chǎn)地：美國
  • 貨號：592916
  • cas：26544-34-3
  • 發(fā)布日期： 2022-07-20
  • 更新日期： 2024-08-12
產(chǎn)品詳請
產(chǎn)地 美國
品牌 MedKoo
貨號 592916
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 1.0mg; 5.0mg; 10.0mg; 25.0mg;
CAS編號 26544-34-3
純度 >98%%
是否進口 是
Description: Apiin is a polyketide synthase-derived flavonoid glycoside that has been found in A. graveolens and has diverse biological activities. It inhibits Aurora B kinase in a cell-free assay using the human enzyme (IC50 = 12.14 μM). Apiin (10 and 50 μg/ml) inhibits LPS-induced increases in nitric oxide (NO) release and inducible nitric oxide synthase (iNOS) levels in J774.A1 macrophages. It scavenges DPPH, superoxide, and hydroxyl radicals (IC50s = 68, 390, and 48 μg/ml, respectively), as well as increases the levels of superoxide dismutase (SOD) and catalase in mouse serum, brain, heart, liver, and kidney when administered at a dose of 50 mg/kg.

Synonym: Apiin;

IUPAC/Chemical Name: 7-((2-O-beta-D-Apiofuranosyl-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyranone

InChi Key: NSVHIOLUPMJKID-RQUVOORVSA-N

InChi Code: InChI=1S/C26H30O14/c27-9-17-20(31)21(32)22(39-25-23(33)26(34,10-28)11-36-25)24(38-17)37-14-7-16(30)15-5-6-18(40(35)19(15)8-14)12-1-3-13(29)4-2-12/h1-4,6-8,17,20-25,27-34H,5,9-11H2/t17-,20-,21+,22-,23+,24-,25+,26?/m1/s1

SMILES Code: O=O1C2=CC(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O[C@H]4[C@@H](C(CO4)(CO)O)O)=CC(O)=C2CC=C1C5=CC=C(O)C=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00