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Ambrisentan
  • 品牌：MedKoo
  • 產(chǎn)地：美國
  • 貨號：326690
  • cas：177036-94-1
  • 發(fā)布日期： 2022-07-20
  • 更新日期： 2024-08-12
產(chǎn)品詳請
產(chǎn)地 美國
品牌 MedKoo
貨號 326690
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 1.0g; 2.0g; 5.0g; 10.0g; 25.0g; 50.0g; 100.0g; 200.0g;
CAS編號 177036-94-1
純度 >98%%
是否進口 是
Description: Ambrisentan, also known as BSF-208075 and LU-208075, is a drug indicated for use in the treatment of pulmonary hypertension. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2). Ambrisentan was approved by the U.S. Food and Drug Administration (FDA) and European Medicines Agency, and designated an orphan drug, for the treatment of pulmonary hypertension.

Synonym: BSF-208075; BSF208075; BSF 208075; LU-208075; LU208075; LU 208075; Ambrisentan. trade name Letairis; Volibris; pulmonext.

IUPAC/Chemical Name: (S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid

InChi Key: OUJTZYPIHDYQMC-LJQANCHMSA-N

InChi Code: InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

SMILES Code: O=C(O)[C@@H](OC1=NC(C)=CC(C)=N1)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001